Confounding Factors Influencing Amyloid Beta Concentration in Cerebrospinal Fluid
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چکیده
منابع مشابه
Confounding Factors Influencing Amyloid Beta Concentration in Cerebrospinal Fluid
Background. Patients afflicted with Alzheimer's disease (AD) exhibit a decrease in the cerebrospinal fluid (CSF) concentration of the 42 amino acid form of beta-amyloid (Abeta(42)). However, a high discrepancy between different centers in measured Abeta(42) levels reduces the utility of this biomarker as a diagnostic tool and in monitoring the effect of disease modifying drugs. Preanalytical an...
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The concentration of protein in the cerebrospinal fluid (CSF) is about 0.5 per cent that of plasma. This difference in concentration is generally considered (1) to be dependent upon the blood-CSF barrier. The normal concentration gradient of protein from a low level in the ventricles, 6 to 15 mg. per cent, to an intermediate level in the cisterna magna, 15 to 25 mg. per cent, to the highest lev...
متن کاملLow Cerebrospinal Fluid Amyloid-Beta Concentration Is Associated with Poorer Delayed Memory Recall in Women
BACKGROUND Data on the association of memory performance with cerebrospinal fluid (CSF) biomarkers of Alzheimer's disease (AD) are inconsistent. The Consortium to Establish a Registry for Alzheimer's Disease neuropsychological battery (CERAD-NB) is a commonly used validated cognitive tool; however, only few studies have examined its relationship with CSF biomarkers for AD. We studied the correl...
متن کاملThe choroid plexus removes beta-amyloid from brain cerebrospinal fluid.
beta-Amyloid (Abeta) concentration in the cerebrospinal fluid (CSF) of the brain may be regulated by the choroid plexus, which forms a barrier between blood and brain CSF. Abeta uptake from CSF was determined as its volume of distribution (V(D)) into isolated rat choroid plexus tissue. The V(D) of [125I]Abeta1-40 was corrected by subtraction of the V(D) of [14C]sucrose, a marker for extracellul...
متن کاملCerebrospinal Fluid Pressure: Revisiting Factors Influencing Optic Nerve Head Biomechanics
Purpose To model the sensitivity of the optic nerve head (ONH) biomechanical environment to acute variations in IOP, cerebrospinal fluid pressure (CSFP), and central retinal artery blood pressure (BP). Methods We extended a previously published numerical model of the ONH to include 24 factors representing tissue anatomy and mechanical properties, all three pressures, and constraints on the op...
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ژورنال
عنوان ژورنال: International Journal of Alzheimer's Disease
سال: 2010
ISSN: 2090-0252
DOI: 10.4061/2010/986310